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Mechanism of action—

β-lactamase-producing Enterobacteriaceae

  • cUTI and cIAI are associated with serious Gram-negative pathogens, including Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs)1,2
  • Klebsiella pneumoniae carbapenemase—or KPC—is a common subset of carbapenem-resistant Enterobacteriaceae (CRE)3,4
    • KPC is the predominant carbapenemase among Enterobacteriaceae in the US4

AVYCAZ has demonstrated in vitro activity against some β-lactamases and some ESBLs of the following groups5:

A chart showing that B-Lactamase inhibits both KPC and AmpCs
  • AVYCAZ is not active against bacteria that produce metallo-β-lactamases and may not have activity against Gram-negative bacteria that overexpress efflux pumps or have porin mutations5