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Dosing—Renal impairment

Chart of AVYCAZ dosing adjustments  in patients with renal impairment

*As calculated using the Cockcroft-Gault formula.

Both ceftazidime and avibactam are hemodialyzable; thus, administer AVYCAZ after hemodialysis on hemodialysis days.

IV, intravenous.


  • For patients with changing renal function, monitor creatinine clearance (CrCl) at least daily, particularly early in treatment, and adjust the dosage of AVYCAZ accordingly1
  • No dosing adjustment is necessary for AVYCAZ in patients with impaired hepatic function1