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Enterobacteriaceae—Demonstrated in vitro activity against some β-lactamases and some ESBLs of the following groups1:

B-Lactamase inhibits both KPC and AmpCs

ESBLs, extended-spectrum β-lactamases.

KPCs, Klebsiella pneumoniae carbapenemases.

  • Klebsiella pneumoniae carbapenemase—or KPC—is a common subset of carbapenem-resistant Enterobacteriaceae (CRE)2,3
    • KPC is the predominant carbapenemase among Enterobacteriaceae in the US3
  • AVYCAZ is not active against bacteria that produce metallo-β-lactamases and may not have activity against Gram-negative bacteria that overexpress efflux pumps or have porin mutations1